Genetic modification aimed at understanding the function and pathology associated with specific genes is most commonly undertaken in mice, as about 99 percent of human genes have mouse orthologs. 1 ...

Two Americans and one Briton -- Mario R. Capecchi, Oliver Smithies, and Sir Martin Evans, respectively -- have won the Nobel Prize in Physiology or Medicine for developing the technology to manipulate ...

CRISPR-Cas technology has radically changed how transgenic models are created. Through CRISPR approaches, researchers have pioneered how to create complex animal models, including long cassette ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Technologies at the Advanced Rodent Transgenics Laboratory include genome editing design and implementation and transgenic ...

The mouse is a standard laboratory model organism, but there are currently few resources that describe conventional techniques to analyze blood and blood-forming tissues in this species. A newly ...

This microscope image provided by Xiao-Yang Zhao of the Southern Medical University in Guangzhou, China on Thursday, Feb. 25, 2016, shows rudimentary mouse sperm derived from stem cells. The sperm, ...

Using light beads microscopy, researchers can now capture images of a vast number of cells across different depths in the brain at high speed, with unprecedented clarity. Capturing the intricacies of ...